Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.
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A further study suggests that the formation of N-oxide was not limited to formulation only but was also observed in the synthesis of raloxifene .
Please try again later. No part of this content may be reproduced or transmitted in any form or by any means as per the standard guidelines of fair kolliicoat. For instance, wet granulation though remains widely practiced in the industry for its simplicity and easy scale up, can exert an enormous mechanical stress on the excipients caused by multiple formulation steps involving blending, mixing, granulation, drying, and sieving .
Stability condition 3 kolllicoat. J Anal Pharm Res 2 3: We will save your personal data only as long as necessary to respond to your requests. Oxidative degradation of raloxifene may lead to adverse reactions . Unless noted otherwise, the statistical analysis was not performed as all the data points were a single measurement on each individual samples.
Taken collectively, this kollicozt also demonstrates that PEG-PVA was exceptionally stable and did not show koklicoat peroxide increase under the various ambient stability conditions over a 5 years period.
Minimizing the Risks for Oxidative Degradation of Drugs. This graft copolymer with a low viscosity provides additional advantages in other applications such as instant release coating, emulsifier, wetting agent and hydrophilic pore former in sustained release tablets. Industry Please choose your industry.
Thus, minimizing the risks for elevated impurities in the excipients, especially the peroxides, is highly essential, which could otherwise be detrimental to long term stability of pharmaceutical dosages [5 6].
Oxidative degradation has been studied extensively . Please check your mailbox for further information. This study is aimed at examining the impact of peroxides on degradation of drug in formulations prepared by wet granulation and finds the appropriate excipients to mitigate the risks for degradation. Link to reset your password has been sent to your provided E-Mail ID. Thus, PEG-PVA with remarkable properties as binder and coating polymer, and free of peroxides, brings a new generation of excipient that could be widely applied to a range of wet granulation formulation development of highly sensitive drugs prone to oxidative degradation.
Poster Using different coating technologies to apply a functional film-coating polymer onto drug layered pellets Download. In a matrix dosage wherein the drugs and excipients typically are intimately in contact, an elevated level of peroxide may lead to significant oxidation of sensitive drugs, especially those bearing tertiary amines and secondary alcohols.
The aim of this study was to investigate the peroxide free instant release polymer in the instant release matrix tablet and examine the oxidative degradation of raloxifene when used as a wet binder. Please choose your country.
Tablet properties such as tablet weight, thickness, hardness, friability, and disintegration time with PEG-PVA and povidoneK30 were evaluated and found to be comparable with both binders with the individual corresponding amounts used.
Portfolio Overview Focusing on your kollicowt with platform solutions Read. Click here to submit your manuscript Therefore, the efforts continue to identify the appropriate excipients lacking peroxides, or having significantly low peroxides to alleviate the oxidative degradation.
Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs
The hardness of the granules, increased as kollicoag function of compression forces in both fluid bed and high shear granulations.
The stability of active ingredients depends on external factors, e. You will find the unsubscribe link at the end of each newsletter you receive.
In addition, PEG covalently bound to polyvinyl alcohol acts as an internal plasticizer and provides a high flexibility, thus allowing the polymer to overcome the mechanical stress during manufacturing and storage of dosage forms.
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Likewise, the tablets with povidone K30 bearing the low peroxide e. The data from this kollicooat demonstrates that PEG-PVA, lacking the inherent residual peroxides as shown in Table 4, curtails the oxidative degradation of raloxifene in the tablets. If you register for a newsletter, you can unsubscribe at any time. Your personal data might be passed on to affiliated companies or third parties.
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